ea0025p276 | Reproduction | SFEBES2011
Joharatnam Jalini
, Lamanna Giuseppina
, Trew Geoffrey
, Lavery Stuart
, Hardy Kate
, Franks Stephen
Aim: PCOS is associated with peripheral insulin resistance and we have previously shown that glucose uptake and metabolism are impaired in granulosa lutein (GL) cells of anovulatory women with PCOS (anovPCO). The aim of this study was to delineate insulin-signalling pathways in GL cells from women with anovPCO and to compare the response to insulin with that in GL cells from ovulatory women with (ovPCO) and without polycystic ovaries (controls).Methods: ...